Scientific Program

Tuesday October 3, 2017

14:00-16:00 Registration
16:00-16:30 Welcome Words / Yves Desjardins, André Marette

Opening Keynote Lectures
Overview of 25 years of polyphenols research
Dr. Alan Crozier / Dr. Daniele Del Rio
Epigenetic control of cardiovascular health by polyphenols
Dr. Wim van den Berghe
COSMOS Study, Cocoa & cardiovascular health
Dr. Hagen Schroeter

18:00-20:00 Opening Ceremony and Welcome Reception


Wednesday October 4, 2017

  Plenary Lectures
08:30-09:15 Keynote 4: Microbiota
Microbial metabolism of polyphenols, inter-individual response
Dr. F. Tomás-Barberan
09:15-10:00 Keynote 5: TBC
Polyphenols on modulation of gut microbiota in vitro
Tom Van de Wiele
10:00-10:30 Health Break
  SESSION 1: Microbiota
10:30-10:50 Polyphenol and Gut ecology
Kiriam Tuohy
10:50-11:10 Non-absorbable apple procyanidins prevent obesity associated with gut microbial and metabolomic changes 
Toshihiko Shoji
11:10-11:30 Flavonoid Subclass-specific Microbiome Profiles in a large cohort of healthy adult men
Ivey Kerry
11:30-11:50 Daily consumption of orange juice from Citrus sinensis L. Osbeck affects Gut Microbiota Profiling as unveiled by an integrated meta-omics approach
Elisa Brasili
11:50-12:10 Diet enrichment with berry powders stimulates Verrucomicrobiaceae and Coriobacteriaceae families and decreases Firmicutes/Bacteroidetes ratio in high-fat high-sucrose fed mice
Carolina Rodriguez Daza
12:10-13:30 Lunch
Plenary Lectures
13:30-14:00 Keynote 6: Bioavailability & metabolism (Phase II)
Bioactivity of anthocyanin metabolites
Colin Kay
14:00-14:30 Keynote 7: Cognition & gut-brain axis
Polyphenols and cognitive function
Daniel Lamport
14:30-15:00 Health Break
Bioavailability & metabolism
Cognition & gut-brain
SESSION 4 New mode of actions /
New perspectives / Biomarkers
15:00-15:20 Anthocyanin bioavailability and metabolism
Wilhelmina Kalt
Interindividual variation in the preventive effect of blueberry and grape polyphenols on age-related memory alteration in healthy elderly: Neurophenols clinical trial
Stéphanie Dudonné
Chronopharmacology of PAC consumption vs Melatonin synthesis in the Brain
Cintá Bladé
15:20-15:40 Phenolic acid catabolites are predominant biologically active compounds derived from quercetin glycosides
Yoshimasa Nakamura
A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of low dose enhanced wild blueberry powder and wild blueberry extract in maintenance of episodic and working memory in older adults
Claire Williams


15:40-16:00 Gut microbial metabolism of (poly)phenolics in ileal-digested raspberries yields bioactive metabolites, genoprotective in colon cells
Chris Gill
Metabolic / Neuro / Metabolites link
Britt Burton-Freeman 
Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion
Naomi Osakabe
16:00-16:20 Pharmacokinetics and anti-inflammatory activities of six weeks of mango (Mangifera Indica L.) consumption in lean and obese individuals 

Brain studies, including correlations with gut /  microbial-generated metabolites
Barbara Shukitt-Hale


16:20-16:40 Metabolic pathways proposal for the identification of phenolic compounds after the acute intake of red apple skin in human plasma and urine
Iziar Ludwig
Gut microbiota modulation accounts for the anti-neuro-inflammatory properties of anthocyanins
Claudia Marques
Polyphenol and the endocannabinoidome
Goeffrey Guy

Gut metabolism of [U-13C]-quinic acid, the other hydrolysis product of chlorogenic acid
Sofia Moco


dentification of dietary modulators of cognitive function in ageing using metabolomics discovery
Dorrain Low

Kidney inflammation: protective action of (-)-epicatechin
Monica Galleano


Estimated Dietary Intake of Polyphenols in European Adolescents : the HELENA study
Ratih Wirapuspita Wisnuwardani

Bridging (poly)phenols consumption and health: novel opportunities for Parkinsons disease
Ines Figueira

Protein adduction by curcumin
Claus Schneider

17:20-18:30 Poster Session

Thursday October 5, 2017

    Plenary Lectures
08:30-09:00   Keynote 8: Frailty & Healthy Aging
The frailty phenotype and polyphenol exposure towards healthy aging
Dr. Cristina Andres-Lacueva
09:00-9:30   Keynote 9: Oral health/Skin health/UTI
Procyanidin and oral health
Dr. Daniel Grenier
9:30-10:00   Health Break
Polyphenols vs Oral & Skin health / microbiome
Obesity / metabolic syndrome
Cranberry and Health (Cranberry Institute)

ANTHO4SKIN  Recycling anthocyanins for cosmetic applications 
Iva Fernandes

The effect of urolithins on insulin secretion
Catherine Oiry

Cranberry PAC and modulation of immune response
Christian Krueger

Anti-aging effects of ellagitannin metabolites, urolithins, on the skin
Februadi Bastian

Epicatechin and anthocyanins protect the intestinal barrier from high fat diet-induced permeabilization: implications for steatosis and insulin resistance.
Elenora Cremonini

Cranberry and quorum sensing
Nathalie Tufenski

3,4,5-tri-O-caffeoylquinic acid as a potential candidate to induce hair growth and hair pigmentation
Meriem Bejaoui

Polyphenols from Lonicera caerulea L. berry ameliorate experimental nonalcoholic steatohepatitis (NASH) through dual modulation of antioxidant and inflammatory mediators
De-Xing Hou

Cranberry modulation of the gut microbiota
André Marette

The Role of Oral Bacteria in the Bioconversion of Nitrate to Nitrite
Hayat Alzahrani

Polyphenol exposure and risk of type 2 diabetes: a systematic review and dose-response meta-analysis of prospective cohort studies
Johanna Rienks

Bioavailability of Cranberry polyphenols
Ana Rodriguez-Mateos

Melanogenesis Regulatory Effect of Tara tannin
Thanyanan Chaochaiphat

Resveratrol improves hypothalamic leptin sensitivity and potentially contributes to body weight loss in obesity 
Gerard Aragones

Cranberry decreases the recurrence of uncomplicated urinary tract infections in healthy women: a meta-analysis
DeAnn Liska


Amelioration of endoplasmic reticulum stress and improving mitochondrial biogenesis and function as the key mechanisms of nonalcoholic fatty liver disease protection by dietary polyphenols
Hossein Rafiei

Dose-response effect of an apple extract on postprandial glycaemia: a randomized controlled trial
Emily Prpa

Animal and human studies on the beneficial effects of cranberry juice on heart disease
Joe Vinson


Modulation of postprandial glycaemia, appetite and gut hormones with spice-based beverages: two randomized, crossover study in healthy subjects
Yoghatama Cindya Zanzer

Impact of a cranberry extract on weight loss and glucose tolerance in obese mice exposed to persistent organic pollutants
Béatrice Choi
12:20-13:30   Lunch
    Plenary Lectures
13:30-14:00   Keynote 10: Cardiovascular health and renal diseases
Impact of phenolic acids of coffee and whole grain on human vascular funcion
Jeremy Spencer
14:00-14:30   Keynote 11: New analytical tools and strategy
Non-targeted LC-MSn approaches to assess polyphenol composition, diversity and bioavailability
Gordon McDougall
14:30-15:00   Health Break
Cardiovascular health and renal diseases
Analytical tools
Valorization of Amazon/Nordic plants

Flavonoid-rich apple improves endothelial function in individuals at risk for cardiovascular disease: a randomised controlled clinical trial
Nicola Bondonno

MetaboAnalyst platform Phenol-Explorer
David Wishart

Stressed for Success: Arctic berry healing properties for skin repair and metabolic health 
Mary Ann Lila


Improvements in cardio-metabolic health following 6-month blueberry intake: a dose-response randomised controlled trial in adults with metabolic syndrome
Peter Curtis

Scientific substantiation of health claims made on polyphenol-rich foods pursuant to Regulation (EC) No 1924/2006 
Daniela Martini
Camu camu (Myrciaria dubia) phytonutrients prevent obesity by altering the gut microbiota and increasing brown adipose tissue activation in diet-induced obese mice
Fernando Anhê

Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: a randomized controlled trial
Goeffrey Istas

A tale of promiscuity: molecular perspectives of polyphenols and their protein interactions
Sofia Moco

Quebecol, a new polyphenol from maple tree (Acer saccharum L.) sap with beneficial health effects
Normand Voyer

Acute vascular effects of phenolics-rich oats in men with pre- or stage 1 hypertension
Manuel Schar

Bacterial enzymes as a useful tool for the preparation of polyphenolic Phase II metabolite standards
Katerina Valentová
Prebiotic action of specific polyphenol fractions from Nordic fruits on gut microbiota and energy metabolism
Yves Desjardins

Effects of green tea consumption on micro- and macrovascular function under metabolically challenging conditions in healthy men
Kirsty Roberts

PhytoHub, an online platform to gather expert knowledge on polyphenols and other dietary phytochemicals
Claudine Manach

Inhibition of angiotensin converting enzyme activity by phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg)
Gabriela Santiago

Ferulic acid and its derivatives modulate nitric oxide balance in HUVEC cells
Giulia Corona

Characterization and comparative analysis of bioactive compounds in legumes by non-targeted metabolomic approach using LC-MS-Orbitrap
Raphael Llorach

Phenolic-rich Sabara jaboticaba extracts prevent obesity and improve parameters related to glucose metabolism in high-fat-sucrose diet-fed C57BL/6 mice
Caldas Moura Márcio Hercules



Bri  UPLC-HR-QTO-MS Metabolite Profiling and Bioaccessibility of Polyphenols
Bhimanagouda Patil

17:20-18:30   Poster Session
20:00-23:00   Farewell Banquet

Friday October 6, 2017

  Plenary Lectures
8:30 - 9:00 Keynote 12: Nutrigenomics/epigenetics
Polyphenols modulation of miRNA
Dragan Milenkovic
9:00 - 9:30 Keynote 13: Cancer/IBD/Immunology
Cancer chemopreventive effects of some polyphenols with anti-inflammatory and proresolving properties
Young-Joon Surh
9:30-10:00 Health Break
10:00-10:20 Substantial variability across individuals in the vascular and nutrigenomic response to an acute intake of curcumin: A randomised controlled trial
Christine Morand
Contrasting in vitro vs. human studies to further understand the molecular effects of plant bioactives: the case of the urolithins against colon cancer 
García Conesa María Teresa

Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation
Rosemari Otton

Dietary intake of polyphenols and colorectal cancer risk in the EPIC study
Raul Zamora-Ros


Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability
Irana Krga

Targeting colorectal cancer stem cells by citrus polymethoxylated flavones: a 3D cell model approach
Ana Teresa Sera


Glabridin inhibits glucocorticoid-induced muscle atrophy in C2C12 cells and C57BL/6J mice
Hitoshi Ashida

Cancer chemopreventive and chemotherapeutic activities of apple peel flavonoids
Vasantha Rupasinghe
11:30-13:00 Closing Sessions
Overview of flavonoid intake and cardiovascular diseases
Kevin Croft
Antioxidant signaling and cellular function: polyphenol effects
Garry Williamson
Is nitric oxide an ubiquitous molecule involved in health benefits of flavonoids?
Cesar  G.Fraga

Visit of the largest Organic Cranberry Bog in the world (lunchbox included)
(1hr from Québec City)
Return to Québec City